I’m an Assistant Professor at the University of California San Diego in the Department of Molecular Biology. I am also a Faculty Fellow of the San Diego Supercomputer Center.
Christopher T. Lee
Principal investigator
CV
ORCiD
GitHub
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Website
Email
ctlee@ucsd.edu
Papers
Membrane Phase, Charge, and Curvature Regulate α-Synuclein Binding Dynamics
Kou et al., 2026 LangmuirPhysics-Guided Neural Reconstruction of Cellular Membranes from Electron Microscopy
Matsuda et al., 2026 In ReviewSaturated Cardiolipins Are Potent Disruptors of Inner Mitochondrial Membrane Structure and Function
Venkatraman et al., 2026 J. Biol. Chem.Size-Dependent Nucleus-Vacuole Interactions in Budding Yeast Demonstrate a Role for Steric Packing in Organelle Shape and Positioning
Mirvis et al., 2026 In ReviewLight-Guided Actin Polymerization Drives Directed Motility in Protocells
Matsubayashi et al., 2026 In ReviewMechanochemical Feedback between Confinement and Actin Crosslinking Drives the Shape Dynamics of Liquid-like Droplets
Mansour et al., 2026 Nat. Commun.Local Enrichment of Cardiolipin to Transient Membrane Undulations
Lee et al., 2025 Biophys. J.Spatial Modeling Algorithms for Reactions and Transport in Biological Cells
Francis et al., 2024 Nat. Comput. Sci.Membrane mechanics dictate axonal morphology and function
Griswold et al., 2024 Nat. Neurosci.Setting the Curve: The Biophysical Properties of Lipids in Mitochondrial Form and Function
Venkatraman et al., 2024 J. Lipid Res.Modeling the Mechanochemical Feedback for Membrane-Protein Interactions Using a Continuum Mesh Model
Lee et al., 2024 Methods in EnzymologyBiophysical modeling of synaptic plasticity
Lee et al., 2024 Annu. Rev. Biophys.Cristae formation is a mechanical buckling event controlled by the inner membrane lipidome
Venkatraman et al., 2023 EMBO J.SMART: Spatial Modeling Algorithms for Reaction and Transport
Laughlin et al., 2023 JOSSActuAtor, a Listeria-inspired molecular tool for generating force in living cells: Controlled deformation of intracellular organizations
Nakamura et al., 2023 Cell ReportsThe ins and outs of membrane bending by intrinsically disordered proteins
Yuan et al., 2023 Science AdvancesSpatiotemporal Modelling Reveals Geometric Dependence of AMPAR Dynamics on Dendritic Spine Morphology
Bell et al., 2022 The Journal of PhysiologyMem3DG: An open-source software framework for 3-D membrane mechanochemical dynamics using discrete differential geometry on triangulated meshes
Zhu et al., 2022 Biophys. ReportsRole of the Triplet State and Protein Dynamics in the Formation and Stability of the Tryptophan Radical in an Apoazurin Mutant
López-Peña et al., 2022 J. Phys. Chem. BDendritic Spine Morphology Regulates Calcium-Dependent Synaptic Weight Change
Bell et al., 2022 J. Gen. Physiol.Benchmarking Ensemble Docking Methods in D3R Grand Challenge 4
Gan et al., 2022 J. Comput. Aided. Mol. Des.Morphological Principles of Neuronal Mitochondria
Mendelsohn et al., 2021 J. Comp. Neurol.Value of Models for Membrane Budding
Lee et al., 2021 Curr. Opin. Cell Biol.Independent Markov Decomposition: Towards modeling kinetics of biomolecular complexes
Hempel et al., 2021 Proc. Natl. Acad. Sci.Applications and Challenges of Machine Learning to Enable Realistic Cellular Simulations
Vasan et al., 2021 Front. Phys.3D Mesh Processing Using GAMer 2 to Enable Reaction-Diffusion Simulations in Realistic Cellular Geometries
Lee et al., 2020 PLOS Comp. Biol.An Open Source Mesh Generation Platform for Biophysical Modeling Using Realistic Cellular Geometries
Lee et al., 2020 Biophys. J.The Implementation of the Colored Abstract Simplicial Complex and Its Application to Mesh Generation
Lee et al., 2019 ACM Trans. Math. Softw.Structural Basis for Ligand Modulation of the CCR2 Conformational Landscape
Taylor et al., 2019 Proc. Natl. Acad. Sci.Quantitative Ranking of β-cyclodextrin Ligand Binding Kinetics With SEEKR, a Hybrid MD/BD/Milestoning Approach
Jagger et al., 2018 J. Phys. Chem. Lett.Exascale Computing: A New Dawn for Computational Biology
Lee et al., 2018 Comput. Sci. Eng.Two Relations to Estimate Membrane Permeability Using Milestoning
Votapka et al., 2016 J. Phys. Chem. BEmerging Computational Methods for the Rational Discovery of Allosteric Drugs
Wagner et al., 2016 Chem. Rev.Simulation-Based Approaches for Determining Membrane Permeability of Small Compounds
Lee et al., 2016 J. Chem. Inf. Model.Known Structure, Unknown Function: An Inquiry-Based Undergraduate Biochemistry Laboratory Course
Gray et al., 2015 Biochem. Mol. Biol. Educ.Application of Molecular-Dynamics Based Markov State Models to Functional Proteins
Malmstrom et al., 2014 J. Chem. Theory Comput.
Projects
- smart - Spatial Modeling Algorithms for Reactions and Transport
- Mem3DG - 3D computational model for lipid membranes
- membrane-spectral-analysis - Compute fluctuation spectra of biological membranes
- gamer - Geometry-preserving Adaptive Mesher
- ActuAtorForceEstimation - Estimating forces on the membrane by ActuAtor
- casc - Colored Abstract Simplicial Complex Library